How can we make drug discovery more predictable?
3D cell culturing
The trend in the global drug discovery market is towards the usage of 3D cell culturing systems. The reason is that, compared to 2D, 3D cell culturing systems do mimick in vivo natural cell systems better. As a result, these 3D systems will be more predictive for both toxicity testing and drug screening. In the ideal scenario such 3D cell culture systems can replace animal testing, which is a commonly shared public demand.
Fujifilm has developed different new 3D cell culturing scaffold materials such as Honeycomb film and recombinant peptide with a highly reproducible quality. Honeycomb film is a thin macro-molecular film with hexagonally arranged micro-pores. Manufacturing of this biomaterial film is based on the self assembly of micro water droplets in a polymer solution. Honeycomb film can be used for a variety of applications, such as cell culturing.
Another 3D cell scaffold material is Cellnest, a recombinant peptide produced with a biotechnological yeast process. This recombinant peptide is based on the human collagen I sequence and is enriched with arginine-glycine-aspartate (RGD) triplets to enhance cell adhesion. This biomaterial can be produced in various forms, such as sponges, granules, microspheres and films. This way, optimal 3D matrix-cell combinations can be achieved with a highly reproducible quality.