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How can we make drug discovery more predictable?

How can we make drug discovery more predictable?

3D cell culturing

The trend in the global drug discovery market is towards the usage of 3D cell culturing systems. The reason is that, compared to 2D, 3D cell culturing systems do mimick in vivo natural cell systems better. As a result, these 3D systems will be more predictive for both toxicity testing and drug screening. In the ideal scenario such 3D cell culture systems can replace animal testing, which is a commonly shared public demand.

Fujifilm has developed different new 3D cell culturing scaffold materials such as Honeycomb film and recombinant peptide with a highly reproducible quality. Honeycomb film is a thin macro-molecular film with hexagonally arranged micro-pores. Manufacturing of this biomaterial film is based on the self assembly of micro water droplets in a polymer solution. Honeycomb film can be used for a variety of applications, such as cell culturing.

Another 3D cell scaffold material is Cellnest, a recombinant peptide produced with a biotechnological yeast process. This recombinant peptide is based on the human collagen I sequence and is enriched with arginine-glycine-aspartate (RGD) triplets to enhance cell adhesion. This biomaterial can be produced in various forms, such as sponges, granules, microspheres and films. This way, optimal 3D matrix-cell combinations can be achieved with a highly reproducible quality.

Useful link: Fujifilm Biomaterials

  • Fujifilm's Core Technology

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By car

The route from Amsterdam, Utrecht (A2, A27) or from Rotterdam, Breda (A16, A59, A27)

  • From A2, keep bearing right at motorway interchange Everdingen (junction Lexmond), A27 direction Breda;
  • From A16 (Dordrecht/Breda), follow direction Breda; At motorway interchange Zonzeel keep bearing right onto A59. At motorway interchange Hooipolder turn right onto A27.
  1. At motorway A27, take exit Oosterhout/Dongen 19;
  2. Turn right, direction Dongen, Bovensteweg / N629;
  3. Follow direction Tilburg for 10,6 km (follow Industrial Site number 1004/1005);
  4. After 10,6 km, turn left to Burgemeester Letschertweg;
  5. After 2,3 km turn right to Gesworenhoekseweg / Industrial Site number 1004/1005;
  6. Take third exit on the round-a-bout onto Dongenseweg;
  7. After 0.9 km turn right, at the traffic lights, Fujifilm Tilburg is located at the Oudenstaart 1.

The route from Brussels, Antwerpen (A12)

  1. From A12, direction Antwerpen, follow direction Breda;
  2. At motorway interchange Galder keep bearing right onto A27/A58, direction Tilburg;
  3. At motorway, take junction Gilze, Tilburg-West, Rijen (12);
  4. Turn left to N260 / Langenbergseweg (2.7 km);
  5. Straight ahead to Burgemeester Letschertweg, follow direction Industrial Site number 1004/1005 (6.8 km);
  6. After 6.8 km, turn right to Gesworenhoekseweg / Industrial Site number 1004/1005;
  7. Take third exit on the round-a-bout onto Dongenseweg;
  8. After 0.9 km turn right, at the traffic lights, Fujifilm Tilburg is located at the Oudenstaart 1.

The route from Eindhoven (A2)

  1. At motorway interchange Batadorp keep bearing left onto A2, direction Tilburg;
  2. Continue on A58 (21.6 km);
  3. Keep to the right at motrway interchange De Baars en follow A65 direction Tilburg-Noord/‘s-Hertogenbosch/Waalwijk (1.4 km);
  4. Take junction (3) Tilburg-Noord, to N261 direction Waalwijk
  5. Turn right to Burgemeester Bechtweg/N261 (7.0 km). Follow direction Industrial Site number 1004/1005;
  6. Continue on Burgemeester Letschertweg (2.1 km);
  7. Turn left onto Burg. Baron van Voorst tot Voorstweg;
  8. Take first right to Dongenseweg;
  9. After 1.2 km, at the traffic lights, turn left onto Oudenstaart.

The route from s’-Hertogenbosch (A2)

  1. At motorway interchange Empel follow A59 direction RING-Noord/Waalwijk;
  2. At A59, take exit 37-Waalwijk. Continue on A58 (21.6 km);
  3. Follow Midden-Brabantweg/N261 direction Sprang-Capelle/Tilburg/Efteling;
  4. Continue on Midden-Brabantweg/A261, direction Tilburg;
  5. Take exit Tilburg-Noord, to N261, direction Eindhoven/Breda;
  6. Turn right, direction Dongen, to Burgemeester Letschertweg. Follow Industrial Site number 1004/1005;
  7. After 2,1 km, turn left to Burgemeester Baron van Voorst tot Voorstweg;
  8. Take first right to Dongenseweg;
  9. After 1.2 km, at the traffic lights, turn left onto Oudenstaart.

Public Transport

(www.9292ov.nl)

• From Central Railway Station Tilburg: Bus 127, direction /Breda

• Departure from Central Railway Station: every half hour

• Departure from Dongenseweg: every half hour

• Bus stop: Dongenseweg across from the Fujifilm Tilburg entrance